Quick Description
This High-Protein Cheesy Chicken Biscuit Casserole is warm, creamy, and packed with tender chicken, fluffy biscuit pieces, and melty cheddar cheese. Everything bakes together in a rich, savory sauce for the ultimate one-pan comfort meal that’s perfect for busy weeknights or cozy family dinners.
Servings & Timing
Serves: 6
Prep Time: 15 minutes
Bake Time: 30–35 minutes
Total Time: ~50 minutes
Ingredients List
- 2 cups cooked chicken, shredded or cubed
- 1 can (10.5 oz) cream of chicken soup
- ½ cup sour cream
- 1½ cups shredded cheddar cheese (divided)
- 1 can (16.3 oz) refrigerated biscuits, cut into quarters
- ¼ cup milk
- ½ tsp garlic powder
- ½ tsp onion powder
- Salt & black pepper, to taste
- 2 tbsp butter, melted
Instructions
1. Preheat Oven
Preheat oven to 375°F (190°C). Lightly grease a 9×13-inch baking dish.
2. Make the Sauce
In a large bowl, mix:
- Cream of chicken soup
- Sour cream
- Milk
- Garlic powder
- Onion powder
- Salt and pepper
Stir until smooth.
3. Add Chicken & Biscuits
Fold in cooked chicken and biscuit pieces.
Add 1 cup of shredded cheddar cheese and mix gently.
4. Assemble
Pour mixture into prepared baking dish and spread evenly.
Sprinkle remaining ½ cup cheese on top.
Drizzle melted butter evenly over the casserole.
5. Bake
Bake uncovered for 30–35 minutes, until biscuits are cooked through and top is golden and bubbly.
6. Rest & Serve
Let rest for 5–10 minutes before serving.
Nutrition (Per Serving – Approximate)
Calories: 460
Protein: 34g
Carbs: 32g
Fat: 22g
Fiber: 2g
Sugar: 5g
Benefits
- High-Protein Meal – chicken + cheese keep it filling
- One-Dish Dinner
- Family-Friendly
- Great for Leftover Chicken
- Perfect for Meal Prep
Additional Notes
- Use rotisserie chicken for quick prep
- Add peas or broccoli for veggies
- Swap cheddar for Colby-Jack or mozzarella
- Use low-fat sour cream for lighter version
Dietary Info
High-Protein: ✅
Vegetarian: ❌
Gluten-Free: ❌
Low-Carb: ❌
Keto-Friendly: ❌
Brief Introduction
This casserole is everything you want after a long day — creamy, cheesy, warm, and filling. It’s the kind of meal that feels homemade without much effort.
Step-by-Step Cooking Guide
- Mix sauce
- Add chicken & biscuits
- Stir in cheese
- Pour into dish
- Top with cheese & butter
- Bake
- Rest & serve
Ingredient Details & Substitutions
Chicken:
Breast, thighs, or rotisserie chicken all work.
Biscuits:
Use any refrigerated biscuit brand.
Cheese:
Sharp cheddar gives the best flavor.
Soup:
Cream of mushroom can be substituted.
Recipe Variations & Serving Suggestions
Variations
- Buffalo chicken version
- Chicken bacon ranch
- Broccoli cheddar chicken
- Spicy jalapeño version
Serve With
- Green salad
- Roasted vegetables
- Steamed broccoli
- Garlic bread
Storage & Make-Ahead
Refrigerate: 4 days
Freeze: 2 months
Reheat: oven or microwave
FAQs
Can I use raw chicken?
Cook first for best texture.
Can I prep ahead?
Yes, assemble and refrigerate up to 24 hours before baking.
Are biscuits doughy inside?
If pan is deep, cover loosely last 10 minutes if browning too fast.
Optional Personal Story
This is one of those recipes I make when I want something comforting but effortless. Everyone always goes back for seconds.
